Groove sign is a characteristic feature of a Lymphogranuloma Venereum infection, which causes a double genitocrural fold after healing of either inguinal or perirectal adenopathies that are commonly associated with this condition.
Lymphogranuloma Venereum (LV) is caused by L serotype of chlamydiae Trachomatis infection, which begins as a PAINLESS lesion /ulcer on the surface of the vulva,that heals spontaneously, then up to 3 weeks later it would develop inguinal or perirectal adenopathies that ulcerate and results in abscesses or deep fistulous tracts formation, that when resolution will leave the characteristic clinical groove sign.
Diagnosis is usually established via serology, through complement fixation , though it wouldn't detect the serotype , culture of the pus drained from abscesses and nucleic acid amplification using PCR is now available, though Direct Flourescent Antibody staining remains the most specific and sensitive test for diagnosis.
Management is through Doxycycline or Azithromycin use for 3 weeks, also inguinal/perirectal lymphatic tract abscesses may require surgical drainage.
Lymphogranuloma Venereum (LV) is caused by L serotype of chlamydiae Trachomatis infection, which begins as a PAINLESS lesion /ulcer on the surface of the vulva,that heals spontaneously, then up to 3 weeks later it would develop inguinal or perirectal adenopathies that ulcerate and results in abscesses or deep fistulous tracts formation, that when resolution will leave the characteristic clinical groove sign.
Diagnosis is usually established via serology, through complement fixation , though it wouldn't detect the serotype , culture of the pus drained from abscesses and nucleic acid amplification using PCR is now available, though Direct Flourescent Antibody staining remains the most specific and sensitive test for diagnosis.
Management is through Doxycycline or Azithromycin use for 3 weeks, also inguinal/perirectal lymphatic tract abscesses may require surgical drainage.
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