Monday, November 11, 2013

"THECA"

Theca cells are ovarian stromal cells which are responsible for androgen production.

in many ovarian enlargements, there's hyperproliferatrion or hyperactivity of theca cells, which sometimes my be confusing, So I tried to organize my thinking !


first, at any case of ovarian mass in the childbearing period , work-up for the diagnosis would be the same regardless of the etiology
first do a B-HCG to rule out pregnancy , then Ultrasound examination to determine whether this mass is a simple cystic one or a complex mass and in certain conditions you may need laparoscopy.

Ovarian hyperthecosis : a postmenopausal female presenting with virilizing symptoms, UNILATERAL flank pain and palpable adnexal mass, note that one of the differentiating factors between this condition and granulosa-theca cells cancer would be Ultrasonography, estrogen levels, endometrial thickness , endometrial hyperplasia and virilization.

it's a benign condition that's treated through OCPs administration , to reduce gonadotrpins release.

During Pregnancy, theca lutein cyst may develop , notice that ovarian hyperthecosis develop in postmenopausal females due to excessive LH stimulation and lack of inhibitory estrogen effect , in pregnancy theca lutein cysts develop in certain conditions like molar pregnancies and twin pregnancies where there's exessive stimulation this time through placental B-HCG,

theca lutein cysts will regress spontaneously after pregnancy.

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