Theca cells are ovarian stromal cells which are responsible for androgen production.
in many ovarian enlargements, there's hyperproliferatrion or hyperactivity of theca cells, which sometimes my be confusing, So I tried to organize my thinking !
first, at any case of ovarian mass in the childbearing period , work-up for the diagnosis would be the same regardless of the etiology
first do a B-HCG to rule out pregnancy , then Ultrasound examination to determine whether this mass is a simple cystic one or a complex mass and in certain conditions you may need laparoscopy.
Ovarian hyperthecosis : a postmenopausal female presenting with virilizing symptoms, UNILATERAL flank pain and palpable adnexal mass, note that one of the differentiating factors between this condition and granulosa-theca cells cancer would be Ultrasonography, estrogen levels, endometrial thickness , endometrial hyperplasia and virilization.
it's a benign condition that's treated through OCPs administration , to reduce gonadotrpins release.
During Pregnancy, theca lutein cyst may develop , notice that ovarian hyperthecosis develop in postmenopausal females due to excessive LH stimulation and lack of inhibitory estrogen effect , in pregnancy theca lutein cysts develop in certain conditions like molar pregnancies and twin pregnancies where there's exessive stimulation this time through placental B-HCG,
theca lutein cysts will regress spontaneously after pregnancy.
in many ovarian enlargements, there's hyperproliferatrion or hyperactivity of theca cells, which sometimes my be confusing, So I tried to organize my thinking !
first, at any case of ovarian mass in the childbearing period , work-up for the diagnosis would be the same regardless of the etiology
first do a B-HCG to rule out pregnancy , then Ultrasound examination to determine whether this mass is a simple cystic one or a complex mass and in certain conditions you may need laparoscopy.
Ovarian hyperthecosis : a postmenopausal female presenting with virilizing symptoms, UNILATERAL flank pain and palpable adnexal mass, note that one of the differentiating factors between this condition and granulosa-theca cells cancer would be Ultrasonography, estrogen levels, endometrial thickness , endometrial hyperplasia and virilization.
it's a benign condition that's treated through OCPs administration , to reduce gonadotrpins release.
During Pregnancy, theca lutein cyst may develop , notice that ovarian hyperthecosis develop in postmenopausal females due to excessive LH stimulation and lack of inhibitory estrogen effect , in pregnancy theca lutein cysts develop in certain conditions like molar pregnancies and twin pregnancies where there's exessive stimulation this time through placental B-HCG,
theca lutein cysts will regress spontaneously after pregnancy.
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