Friday, October 25, 2013

Kaposi's Sarcoma

when a patient diagnosed with HIV or suffering from opportunistic infections presents with a skin ulcer (usually a Pink lesion), you have to consider Kaposi's Sarcoma.

Needless to say (a common misconcept) that  Kaposi's Sarcoma is not caused by HIV, yes it occurs secondary to HIV Infection with severe immunosuppresion with CD 4 cell count less than 100 cells/mm3,
but the causative agent is Human Herpes Virus 8 "HHV-8" (A DNA virus not an RNA virus !)

the best management is HAART regimen to manage Immunosuppresion, also liposomal Doxorubicin or Vinblastine are used in treatment.

classic picture is a mouth with a  jaw lesion/ulcer with extensive oral candidiasis

            http://www.thecancerblog.org/images/blogs/7-2007/kaposi-sarcoma-5481.jpg



                   http://hardinmd.lib.uiowa.edu/pictures22/cdc/6058_072_lores.jpg

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